NR3C1 and asthma: Glucocorticoid insensitivity is a serious and complicated problem in asthma (Adcock and Ito, 2004; Durham et al., 2011), mainly owing to the defective ligand to the glucocorticoid receptor, abnormal receptor nuclear translocation and abnormal combination with proinflammatory nuclear proteins (Adcock et al., 2008; Barnes and Adcock, 2009; Tonello and Poli, 2009).