CASP3 and colon carcinoma: Besides the cell cycle block, the extract of F. caperata also induced apoptosis via caspase 3 activation that is possible also due to usnic acid since Bačkorová et al. showed that usnic acid induced in the colon carcinoma cell line HT29 apoptosis via caspase 3 activation (Backorova et al., 2012).