ERBB2 and breast carcinoma: However, a clinical phase II trial has indicated there is no benefit from afatinib alone or when combined with the microtubule assembly inhibitor vinorelbine (Jim Yeung, 2005) compared with treatment of the investigator’s choice in women suffering from HER2-positive breast cancer with progressive brain metastases during or after therapy with trastuzumab, lapatinib, or both (Cortés et al., 2015).