In our study, we find that autophagy-related molecules LC3 and Beclin1 are down-regulated in ectopic and eutopic ESCs of patients with endometriosis compare to the ESCs of patients with leiomyoma, and the expression of LC3 and Beclin1 in ectopic ESCs is also significantly lower than in the eutopic ESCs. This evidence concerns the gene MAP1LC3A and endometriosis.