RHAG and neoplasm: In mice with transplanted-tumor via inoculating S180 cells under skin, administration of GS-Rh2 inhibited tumor growth and reduced LVD, indicating that the expression of junction adhesion molecule was weakened and that the lymphangiogenesis in xenograft inhibited after treatment with GS-Rh2 (Wang Q. et al., 2008) (Figure 2).