In this high Ang II-induced hypertensive HF, Ang II type 1 receptor, bound to Ang II, may activate transforming growth factor-β1 (TGF-β1), which subsequently promotes deposition of the extracellular matrix (ECM) and sensitize fibroblast-to-myofibroblast transition (Nagpal et al., 2016). Here, AGT is linked to hypertensive disorder.