Mutations in the protein Atlastin – an ER-tubule binding protein previously discussed – are responsible for 10% of autosomal dominant cases of Hereditary Spastic Paraplegia, a disease characterized by progressive weakness and loss of motor control in the lower limbs (Fink, 2013; Ozdowski et al., 2015). This evidence concerns the gene ATL1 and hereditary spastic paraplegia.