For example, mutations in HSPB1, 3, and 8 are associated with Charcot-Marie-Tooth Disease (Mymrikov et al., 2011) and mutations in HSPB8 are also associated with hereditary spastic paraplegic neuropathy (Mymrikov et al., 2011), two diseases associated with axonal degeneration. This evidence concerns the gene HSPB1 and Charcot-Marie-Tooth disease.