ERN1 and nervous system disorder: In Drosophila, knockdown of atlastin orthologs leads to ER network fragmentation in dendrites, though dendritic arborization defects only resulted when the knockdown was combined with a knockdown of inositol-requiring enzyme-1 (IRE1) (see section “Protein Synthesis Linked to Neurological Disease”) (Liu et al., 2019; Summerville et al., 2016).