Simulations of the mouse PrP showed that the pathogenic mutation D178N associated with inherited CJD or fatal familial insomnia lowered the stability of the β-sheet (Barducci et al., 2005) and another group attempted to map the unfolding of the entire structured domain of PrP (Chamachi and Chakrabarty, 2017; Singh et al., 2017). Here, PRNP is linked to Creutzfeldt Jacob disease.