Moreover, in an AD model, IL4/STAT6 signaling hurt astrocyte survival in vivo (Mashkaryan et al., 2020), and in vitro, IL-4 rescued the impairment of proliferation and neurogenic ability of primary human cortical astrocytes by Aβ42-induced via IL-4/STAT6 pathway (Papadimitriou et al., 2018). This evidence concerns the gene STAT6 and Alzheimer disease.