PRKG1 and early-onset autosomal dominant Alzheimer disease: In pathway enrichment analyses, the DEPs were related to the pentose phosphate pathway (00030), proteasome (03050), the cyclic guanosine monophosphate-protein kinase G (cGMP–PKG) signaling pathway (04022), vasopressin-regulated water reabsorption (04962), amoebiasis (05146), glycolysis/gluconeogenesis (00010), hippo signaling pathway (04390), oxidative phosphorylation (00190), and Alzheimer’s disease (05010) (Figure 6A).