MiR-345-5p may act as blood biomarker in multiple sclerosis (Freiesleben et al., 2016), and miR-345-3p attenuated apoptosis and inflammation caused by oxidized low-density lipoprotein by targeting TRAF6 via TAK1/p38/NF-kB signaling (Wei et al., 2020). This evidence concerns the gene TRAF6 and multiple sclerosis.