We would like to point out that the genetic link between TBK1 and neurodegeneration is largely based on Mendelian dominantly inherited deleterious loss-of-function mutations (such as splice site or frameshift mutations), which are enriched in ALS/FTD patients and result in a loss of expression of one TBK1 allele (Freischmidt et al., 2015). This evidence concerns the gene TBK1 and amyotrophic lateral sclerosis.