Previous reports indicate that obesity and disturbances in leptin signaling markedly affect the expression of neuronal and glial proteins and that leptin binding to its receptor, which is expressed at a remarkably high level in the hippocampus (Caron et al., 2010), is required for neurogenesis and efficient synaptic transmission (Grillo et al., 2011; McGregor and Harvey, 2018). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.