F2 and blood coagulation disease: In our previous clinical study, the mentioned coagulopathy parameters (elevated D-dimer, abnormal PT, and thrombocytopenia), or disseminated intravascular coagulation scores, which also reflect thrombus formation, were each independently associated with an increased risk of PTCI, further indicating that TIC was also associated with post-traumatic cerebral ischemia (Chen et al., 2013).