It impacts endosomal, lysosomal and autophagosomal pathways (Roosen and Cookson, 2016; Alessi and Sammler, 2018), which are also affected by other well-defined PD genes, such as SNCA and GBA1 (Blandini et al., 2019), strongly implicating these fundamental cellular processes in PD pathophysiology. This evidence concerns the gene GBA1 and Parkinson disease.