LRRK2 and Parkinson disease: In light of the gain of toxic kinase function hypothesis in Parkinson’s disease, measures of LRRK2 kinase function are of particular interest, for instance the measure of LRRK2 autophosphorylation sites, including the S1292 site that has robustly been confirmed on endogenous LRRK2 in model systems as well as in human samples.