The results revealed that insulin use (OR = 0.463, p = 0.046), hypertension (OR = 5.266, p = 0.000), HbA1c (OR = 1.298, p = 0.003), and plasma sLRP1 levels (OR = 0.971, p = 0.005) were associated with MCI in patients with T2MD. This evidence concerns the gene INS and hypertensive disorder.