LRP1 and Alzheimer disease: Three meta-analysis have attempted to explore the association between the LRP1 rs1799986 polymorphism and AD susceptibility, one of which reported a weak correlation between the LRP1 CC genotype and AD (Sanchez-Guerra et al., 2001), while the other two showed no positive association between this polymorphism and AD risk (Pritchard et al., 2005) in a Chinese population (Yang et al., 2015).