Research shows that patterns of DNA methylation in spermatozoa of patients with infertility significantly change at different imprinted loci (MEST, LIT1, SNRPN, PEG3, PLAGL1, IGF2, and H19) (Hammoud et al., 2010[18]; Minor et al., 2011[28]). The gene discussed is MEST; the disease is Infertility.