Research shows that patterns of DNA methylation in spermatozoa of patients with infertility significantly change at different imprinted loci (MEST, LIT1, SNRPN, PEG3, PLAGL1, IGF2, and H19) (Hammoud et al., 2010[18]; Minor et al., 2011[28]). This evidence concerns the gene PEG3 and Infertility.