MAPK8 and Insulin resistance: Removal of intrahepatic macrophages in the liver tissue with chlorination improves intrahepatic inflammation independent of JNK phosphorylation and reduces circulating inflammatory factors and prevents high-fat diet-induced hepatocyte and systemic insulin resistance [8, 9], suggesting that macrophage-mediated inflammation in the liver plays an important role in the liver and systemic insulin resistance caused by high fat.