AKT1 and neoplasm: The staining revealed a significant decrease (p < 0.05) in phosphorylation levels of AKT in the tumor derived from the W3-KO tumors as well as from the tumors derived from W3-Y4, compared to the tumors derived from the parental cells (GFP) or the tumors derived from W3-WT, both for MDA-MB-231 (Fig. 7a, b) and 4T1 cells (Fig. 7c, d).