Gene set enrichment analysis was performed using the online tool “genomic regions enrichment of annotations tool” (GREAT).20 Hypermethylated DMPs were significantly enriched at genes associated with embryonal and renal development including PAX2, HNF1β, SOX9 and WNT9B, as well as cancer and development-related pathways such as the Wnt signalling pathway. Here, PAX2 is linked to cancer.