In liver diseases, SHP2 has been reported to promote hepatocyte regeneration after liver injury through regulating the AKT and ERK1/2 signaling pathways, and SHP2 knockout mice displayed very similar phenotypes of defective liver regeneration triggered by partial hepatectomy, including blunted ERK1/2 activation and AKT inhibition [29]. The gene discussed is MAPK3; the disease is liver disorder.