CD276 and colorectal carcinoma: As shown in Supplementary Fig. S1a, B7-H3 was frequently upregulated in the CRC cell lines (RKO, HCT116, HCT8, HT29, SW480 and SW620) compared to the human colon healthy cell line (NCM460), suggesting B7-H3 overexpression has a crucial role in CRC progression.