CD276 and colorectal carcinoma: Given that B7-H3 exerts a key effect on CRC radioresistance in vitro, we further used 3E8, a special B7-H3 blocking antibody that obviously enhanced the radiosensitivity of CRC cells in vitro (Supplementary Fig. S3a), to further determine the role of B7-H3 in regulating CRC radioresistance.