Furthermore, enhanced Bcl-2 expression and reduced Bax and cleaved-caspase 3 expression were observed in B7-H3-overexpressing CRC cells after 4 Gy X-ray irradiation (Fig. 2e and Supplementary Fig. S2c), while downregulated Bcl-2 expression and upregulated Bax and cleaved-caspase 3 expression were observed in B7-H3-knockdown CRC cells after 4 Gy X-ray irradiation (Fig. 2f and Supplementary Fig. S2d). The gene discussed is BAX; the disease is colorectal carcinoma.