In contrast, the Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT study) showed that the use of an ACE inhibitor and a statin did not change albumin—to-creatinine ratio (ACR), carotid intima-media thickness or other CVD markers in adolescents (10–16 years) with T1D, over a median period of 2.6 years [15]. This evidence concerns the gene ACE and type 1 diabetes mellitus.