Compared with the other subtypes of prostate cancer, NEPC expresses specific neuroendocrine markers including synaptophysin (SYP), chromogranin A (CgA), and neuronal‐specific enolase (NSE), with concurrent absence of androgen receptor (AR) and prostate‐specific antigen (PSA) [4]. The gene discussed is SYP; the disease is prostate carcinoma.