Of note, immunostaining showed that all seven tumors were adenocarcinomas before the treatment, evidenced by staining positive for both AR and PSA, and staining negative for SYP, CD56, and CgA, whereas most of them became AR‐ and PSA‐negative, and SYP‐, CD56‐, and CgA‐positive after ADT (supplementary material, Figure S5A). This evidence concerns the gene SYP and adenocarcinoma.