PTEN and pancreatic intraductal papillary-mucinous neoplasm: As PTEN has previously been shown to be highly expressed in pancreatic ducts and centroacinar cells and inhibits IPMN (49, 50), we probed for PTEN expression, which confirmed high levels of PTEN in cKras0 and cKrasLow ducts; however, we observed a significant reduction in PTEN in cKrasMod and cKrasHigh PanIN and PDAC (Fig. 6i).