KRAS and pancreatic intraductal papillary-mucinous neoplasm: As adult pancreatic epithelial cells are refractory to invasive PDAC formation when expressing physiologic levels of Kras without loss of tumor suppressor gene and previous manuscripts have shown that cKras can produce PDAC from acinar cells [19, 51], we employed the cKras allele to study PanIN, IPMN, or and PDAC arising in adult pancreatic ductal cells.