To identify potential biomarkers of irAE in anti-PD-1/PD-L1 therapy, we retrieved from the US Food and Drug Administration Adverse Event Reporting System (FAERS) a total of 52,282 adverse events (AEs) from 18,706 patients for 26 different cancer types receiving anti-PD-1/PD-L1 therapy. The gene discussed is CD274; the disease is cancer.