Considering that NRF2 suppresses antiviral IFN-responses, it was surprising to discover that treatment of Vero cells with 4-OI generated before infection with SARS-CoV2 (strain #291.3 FR-4286 isolated from a patient in Germany) resulted in a 102–104 reduction in SARS-CoV2 RNA levels in a dose dependent manner (Fig. 2a, b) while not affecting cell viability, as determined by lactate dehydrogenase (LDH) release assay (Supplementary Fig. 2). Here, NFE2L2 is linked to infection.