In addition, miR-140-5p also could target ORC1 (origin recognition complex 1) in cervical cancer35, PAK4 (p21-activated kinase 4) in oral squamous cell carcinoma36, and IGF1R (insulin-like growth factor-1 receptor) in clear cell renal cell carcinoma37 to affect cell cycle of tumor cells. This evidence concerns the gene ORC1 and neoplasm.