Such cytokines attract T cells that, in turn, produce TNF-α and IFN, which activate endothelial and dendritic cells that respond by producing more cytokines, especially IL-1 and IL-6.12 This positive feedback system is harmful to the host, as it results in the induction of cell apoptosis and necrosis, diffuse alveolar lesion, fibrin deposition, pulmonary fibrosis and SARS syndrome,7 which is the main cause of death in patients with COVID-19.13 This evidence concerns the gene IFNA1 and COVID-19.