Interestingly, although OS is a tumor of mesenchymal origin, upregulated genes in MG-OKS cells included epithelial-related genes, such as small proline-rich protein 2A (SPRR2A), SPRR1A, keratin 6A (KRT6A), and keratin 6B (KRT6B). The gene discussed is KRT6B; the disease is neoplasm.