Alzheimer’s disease (AD) neuropathological brain lesions consist of aggregates of hyper-phosphorylated tau proteins, which have also been called neurofibrillary tangles (NFTs), and extracellular deposits of amyloid precursor protein (APP) derived amyloid-beta (Aβ) peptides, which are known as amyloid plaques. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.