TRPV1 and neoplasm: As shown in Table 1, the down-regulation of TRPV1 expression was correlated with the large tumor size (P < 0.001), high histological grade (P = 0.006), lymphatic metastasis (P = 0.001), and advanced clinical stage (P < 0.001), but not associated with patients’ age (P = 0.476), gender (P = 0.223).