Similarly, dys- or hyper-lipidemia was induced after a long-term exposure of Zinc oxide (ZnO) NPs via intratracheally instillation in rat, or of TiO2 NPs in ICR or ApoE−/− mice, ultimately contributing to the initiation and progression of atherosclerosis [24, 47, 48]. The gene discussed is APOE; the disease is hyperlipidemia.