UBE2C and non-small cell lung carcinoma: These findings could be partly explained by the fact that in NSCLC, UbcH10 overexpression causes the SAC components Mad2 and BubR1 to prematurely dissociate from the APC/C complex and to be degraded by activated APC/C, which also degrades CyclinB, resulting in mitotic slippage, chromosomal instability and malignant proliferation.