To further validate this finding, we performed immunohistochemical staining on tissue samples obtained from patients with lung squamous cell carcinoma or lung adenocarcinoma and observed the spatial colocalization of UbcH10 and KIAA0101 in SK-MES-1 cells and both lung squamous cell carcinoma and lung adenocarcinoma samples (Fig. 2c). The gene discussed is UBE2C; the disease is lung adenocarcinoma.