For instance, Hai Gao et al. reported that lncRNA ZEB2-AS1 was involved in encouraging tumor growth and invasion of PC through the ZEB2-AS1/miR-204/HMGB1 ceRNA network [26]; Xiong et al. indicated that GSTM3TV2 functioned as a ceRNA and negatively regulated let-7 expression, thereby leading to the PC progression and chemo-resistance through upsetting the expression of LAT2 and OLR1 [27]; Li et al. demonstrated that NORAD may function as a ceRNA to regulate the expression of the small GTP binding protein Rho A through competition for hsa-miR-125a-3p, thereby promoting EMT [28]. This evidence concerns the gene HMGB1 and pachyonychia congenita.