For example, tyrosine kinase non receptor 2 (TNK2) promotes androgen receptor transcription and is a critical oncogene in castration-resistant prostate cancer [28], while the retinoic acid synthesis enzyme aldehyde dehydrogenase 1 family member A2 (ALDH1A2) is a known candidate tumor suppressor associated with decreased colony formation in PCa cell lines [29]. This evidence concerns the gene AR and neoplasm.