C3 and asthma: We found that C3 proteins enrichment in some pathways has a lower p value, which has been reported to be associated with asthma (PMID), such as: neuropeptide Y may promote TH2 inflammatory response in asthma [28], signal transduction of IL-13 plays a role in the pathogenesis of bronchial asthma [29], humoral immune responses during asthma [30].