Higher abundances of pathogenic effector Th2 cells (peTh2 cells) were detected in patients with EoE; which were chemoattractant receptor-homologous molecule-positive (CRTH2+), hematopoietic prostaglandin D synthase-positive (HPSD+), and CD161 high CD4+ T cells [22,77,78]. The gene discussed is CD4; the disease is eosinophilic esophagitis.