Moreover, intriguingly, GLUT12/Glut12 expression was found to be upregulated in the frontal cortex of patients with Alzheimer’s disease (AD) [30] and in the brain of AD mouse models, aged mice, and in mice upon receiving intracerebroventricular injection of Aβ oligomers [34]. Here, SLC2A12 is linked to early-onset autosomal dominant Alzheimer disease.