SOD2 and ischemia: Recently, our research revealed that PGC-1α is an important transcriptional regulator that acts through regulating the expression of reactive oxygen species (ROS), mitochondrial UCP2, superoxide dismutase 2, and mitochondrial biogenesis, which plays a beneficial part in neuroprotection in the CNS following global ischemia and status epilepticus [5,26,28,41,47].