For confirming the specific effect of pgc-1α siRNA on VEGF expression, after a pre-treated microinjection with siRNA against pgc-1α (2 μg) into bilateral hippocampal CA3 region, significant decrease of the vegf mRNA level was shown in our real-time PCR data (Figure 3c), and western blot analysis also confirmed a drastically decline in the VEGF protein level in the hippocampal CA3 area 6 h after KA-induced status epilepticus (Figure 3d) compared with the pre-treatment of the control siRNA group. The gene discussed is PPARGC1A; the disease is status epilepticus.