In the present study, our results suggested activation of VEGF/VEGFR2 (Flk-1) by PGC-1α subsequently activates PI3K/AKT and MEK/ERK signaling by alternating the activation state of numerous of downstream proteins relevant to cell proliferation and inhibiting apoptosis in the hippocampus following status epilepticus. The gene discussed is AKT1; the disease is status epilepticus.