To determinate whether the PGC-1α regulates the survival signaling pathway, PI3K/Akt, through VEGF/VEGFR2 activation in the hippocampus following KA-induced status epilepticus, we delineated the regulatory effects of the PGC-1α activator and siRNA against pgc-1α on PI3K/Akt signaling. The gene discussed is PPARGC1A; the disease is status epilepticus.