To determinate whether the PGC-1α regulates the survival signaling pathway, PI3K/Akt, through VEGF/VEGFR2 activation in the hippocampus following KA-induced status epilepticus, we delineated the regulatory effects of the PGC-1α activator and siRNA against pgc-1α on PI3K/Akt signaling. This evidence concerns the gene KDR and status epilepticus.