Therefore, following status epilepticus, endogenous activation of PGC-1α may regulate the VEGF/VEGFR2 (Flk-1) signaling pathway that triggers PI3K/AKT and MEK/ERK cascades and also promotes the cAMP-CREB signaling axis [45,69], which regulates the anti-apoptotic B-cell lymphoma-2 (Bcl-2) family, the expression of autophagy [63] and lysosomal genes, and further contributes to neuron survival mechanisms in hippocampal neuronal cells [70,71,72]. Here, CREB1 is linked to status epilepticus.