In the present study, we propose that PGC-1α may be activated during experimental status epilepticus and regulate the VEGF/VEGFR2 signaling pathway, and further protects against apoptotic neuronal cell death in the hippocampus following status epilepticus through survival signaling and PI3K/AKT and MEK/ERK-dependent pathways. This evidence concerns the gene VEGFA and status epilepticus.