Confirming the specificity of pgc-1α siRNA on the protein levels of VEGFR2, after a pre-treated microinjection of pgc-1α siRNA (2 μg) into the bilateral CA3 region, a significant elevation of the expression of vegfr2 mRNA (Figure 5c) and diminishment of VEGF protein in the CA3 subfield 6 h after KA-induced status epilepticus (Figure 5d) compared with the rats with pre-treatment of control siRNA was observed. The gene discussed is KDR; the disease is status epilepticus.