In addition, recent studies have demonstrated that the PGC-1α signaling pathway exerts potential neuroprotective properties in many neurological diseases [26,48,49], such as Alzheimer’s disease [50], Parkinson’s disease [51], acute stroke [28,52], epilepsy [53], and status epilepticus [26,53,54,55]. This evidence concerns the gene PPARGC1A and early-onset autosomal dominant Alzheimer disease.