The gene signature differentiating rat and human cancer subtypes differently prone to progression included the genes BHMT (Betaine-Homocysteine S-Methyltransferase) and GNMT (glycine N-methyltransferase), involved in the maintenance of the hepatocyte SAM (S-adenosylmethionine) level and, hence, in the regulation of the susceptibility to cancer progression [88]. Here, BHMT is linked to cancer.