The Pacific study showed that the addition of durvalumab (anti PD-L1) after consolidated chemoradiotherapy (CRT) enhanced both progression free survival (PFS) and overall survival (OS) of phase III unresectable non-small-cell lung carcinoma (NSCLC) patients; subgroup analysis showed that survival benefit was achieved in both PD-L1 positive and negative patients [76]. Here, CD274 is linked to non-small cell lung carcinoma.