BIRC5 and cardiomyopathy: Because our previous studies indicated an important role of survivin/NF-κB/p65 pathway activation in cytoprotection against LPS-injury [20,21], similar to Wilson et al. [37], in CLP-induced cardiomyopathy, we hypothesized that simvastatin has significant cell-protective effects in septic AKI but not only by inhibiting of apoptotic cell death but through induction of the important intracellular survival pathways in renal tubular epithelium.