Previous studies have demonstrated that survivin, expressed dominantly in the proximal tubular cells, prevents development of AKI and renal apoptosis induced by various nephrotoxins (such as folic acid, cisplatin) by suppression of expression of the p53 gene [34,35] and in ischemia/reperfusion (I/R) injury through activation of the Notch-2 intracellular signaling pathway [36]. Here, NOTCH2 is linked to acute kidney injury.