Interestingly, those mUM with a “high” TIL immunoscore had upregulation of the CD25/ILR2A, corresponding to regulatory T-cells (Tregs), and thereby creating a TME characterized by immunosuppression directed against tumour antigen-specific effector T cells, B cells, and plasma cells, ultimately leading to immune exhaustion and/or anergy [44,45,46,47]. Here, IL2RA is linked to neoplasm.