Finally, cytotoxicity in NSCLC: A549 with wild-type EGFR gene, PC-9 with a deletion in exon 19 of the EGFR gene, H-1975 bearing mutations T790M and L858R in the EGFR gene, and human lung fibroblasts, MRC-5, was determined. This evidence concerns the gene EGFR and non-small cell lung carcinoma.