Similarly, 3-bromo-4,5-bis(2,3-dibromo-4,5-dihydroxybenzyl)-1,2-benzenediol isolated from the red alga Rhodomela confervoides was able to activate insulin signaling and prevent palmitate-induced insulin resistance by intrinsic PTP1B inhibition (IC50 2.0 μM). This evidence concerns the gene PTPN1 and Insulin resistance.