Reduced the body weight gain, body fat, plasma lipid levels (TC and TG), insulin resistance and plasma leptin/adiponectin ratioAmeliorated the hepatic protein levels: hepatic lipogenesis (PPARγ, SREBP-1c, FAS and LPL), fatty acid β-oxidation (p-ACC and CPT1A), inflammation (TNF-α, NFkB and IL-1β) and antioxidant defense system. Here, LEP is linked to Insulin resistance.