CD40 and cardiovascular disorder: Conversely, 40 g of daily cocoa powder supplementation decreased the expression of Very-late Antigen-4 (VLA-4), Cluster of differentiation 40 (CD40), and Cluster of differentiation 36 (CD36) in monocytes while circulating pro-inflammatory cytokines, including IL-6 and hs-CRP concentrations, remained unchanged in patients with high risk for cardiovascular disease [42].