Similarly, another study showed that adrenal insufficiency significantly enhanced endotoxemia-induced iNOS expression, and nitric oxide (NO) formation caused oxidative stress in the adrenal gland, as evidenced by the increase of lipid peroxidation biomarker (MDA) and the decrease of antioxidant biomarkers (CAT and SOD activity [9]. This evidence concerns the gene SOD1 and Adrenal insufficiency.