For example, three tumor suppressors, including programmed cell death 4 (PDCD4) [38], phosphatase, and tensin homolog (PTEN) [38], and reversion-inducing cysteine-rich protein with Kazal motifs (RECK) [39], have been shown to be regulated by miR-21 in CCA. Here, PTEN is linked to cholangiocarcinoma.