EZH2 and cholangiocarcinoma: On the other hand, miR-200b/c could regulate tumor initiation or sphere formation of CCA by targeting suppressor of zeste 12 homolog (SUZ12), which is one cofactor essential for enhancer of zeste homolog 2 (EZH2) to catalyze trimethylation of histone at lysine 27 (H3K27me3), leading to transcriptional repression of target genes.