In agreement, we observed marked elevation of glycolysis in addition to high OXPHOS, as shown by higher basal OCR, ATP-R, and activity levels of OXPHOS complexes, in three out of four of our melanoma cell lines (a BRAF/NRAF/NF1-wild-type and two BRAF-mutated melanoma cell lines) compared to HDFs. Here, NF1 is linked to melanoma.